2.75 Urine

Notes


Urine contains (excretion):

-> Salts (Affects composition of tissue fluid = osmoregulation)

-> Urea (Part of excretion of metabolic waste)

-> Water (Affects composition of tissue fluid = osmoregulation)

-> NO GLUCOSE


** Varies upon the conditions which a person is operating (environment/circumstances)

2.74 ADH

Notes


ADH = regulates water content of blood / control &alter composition of water in blood / more or less concentrated
--> Anti-diuretic hormone
--> Produced in hypothalamus
--> Flows through bloodstream --> kidney
**concentration must be right for osmoregulation (2.68b)

ADH targets collecting duct specifically
--> Collecting duct where water is selectively reabsorbed into bloodstream
--> ADH controls pores in the wall (more/less porous) to control 'flow' into bloodstream (more ADH ---> more porous)

Consequence of (more) ADH secretion
--> Urine more concentrated (more blood flows back into bloodstream)
--> Lower volume of urine

Questions?
ADH (hot day) = more ADH (more water available for sweat through the skin)
ADH (cold day) = less/no change ADH?
ADH (dehydrated) = more ADH (more water available for use in the body)

2.73 Glucose Re-absorption

Notes


Selective reabsorption of glucose occurs at PCT
--> Glomerula filtrate (glucose) ---reabsorption---> Blood stream

Filtrate contains:
-> Glucose
-> Water (collecting duct)
-> Salt
-> Urea

Urine = NO glucose? Due to filtration at PCT
--> Glucose is selectively reabsorbed (back into bloodstream) and taken out of the nephron system

2.72 Water Re-absorption

Notes


**Bowman's capsule = ultrafiltration ---> dissolved contents of plasma forced to become glomerula filtrate (water/salts/urea/glucose)

Filtration ---> filters out 'too much water' (as filtrate passes through nephron structure and reaches collecting duct)
---> Passing through collecting duct = water removed from filtrate (returned back to blood vessels/blood stream)
----> Water reselected to be reabsorbed into blood stream = 'selected reabsorption of water' occurs in collecting duct

2.71 Ultrafiltration

Notes


Nephron filters blood =
-> Filtered blood ('clean blood')
-> Excreted urine
----> Urine emerges from bottom of nephron (water / salts (NaCl,MgCl) / Urea (Toxic nitrogen waste)

How is urine formed? ULTRAFILTRATION (filtration of molecules)

1. Blood arrives into nephron through afferent arteriole (high blood pressure)
----> Blood vessel branches into coils (glomerulus)
----> Efferent arteriole (smaller diameter) = increase blood pressure flowing out (higher pressure)
**Glomerulus increases blood pressure

2. High pressure forces liquid in blood (plasma) into the inside of Bowman's capsule
----> Plasma contains:
-----------> water / salts / amino acids / glucose / urea)

----> Plasma inside capsule known as 'glomerula filtrate' (contains)

2.70 Nephron Structure

Notes


Process


Nephron = functional part of kidney (filtration/controlling composition of blood)

IN: Blood ---------- Renal artery (branch of aorta) --------> Nephron

OUT: Urine (excreted after filtration) <---- Ureter -------- Nephron

Urine collects in bladder for release
Filtered blood exits through renal vein ---> vena cava

Structure


-> Outer region = cortex {LIGHTER}
---> Inner region = medulla {DARKER}
--------> Inner space = pelvic region (where urine collects, drains down ureter)

**difference in colours = kidney is tubular structure made of tubes

Tube: starts on edge of medulla, moves outwards towards end of cortex, winds in cortex, dips down into medulla, back into cortex where winds again --> Dead end (Bowman's capsule)

Tubular structure (Nephron)

Twisted structure = convoluted tubules (tube)

Tube leading down to pelvic region (where urine is excreted) = Collecting ducts (tube)

Dip into medulla = loop of Henle

Dead end, cup shaped structure = Bowman's capsule

**tight knot of blood vessels (at Bowman's capsule) = glomerulus

* - - - u - - - /

1st convoluted tubule (- - -) = Proximal C.T. (PCT)

2nd convoluted tube (- - -) = Distal C.T (DCT)

---> Arrangement of nephron structure gives different colours of medulla & cortex

NOTE: millions of these structures (Nephrons) within a kidney.

2.69 Urinary System - Describing the Structure

Notes


Urinary system
1. Kidneys (x2) (each with own blood supply / carries out excretion, osmoregulation
2. Ureter (x2) = tube from each kidney = carries urine from kidney to bladder
3. Bladder (x1) = stores urine
4. Urethra (x1) = urine to outside the body by tube through the (penis / vagina)

2.68b Osmoregulation

Notes


"Role of kidney in process of excretion an osmoregulation"

Osmo = 'osmosis'
Regulation = 'to control'

Cells in body
-> Tissue fluid (surrounding cells) = MUST be ISOTONIC with cytoplasm of cells
------> Water (In to cells) = Water (Out of cells) ---> Cells same size/shape, functions properly

**Danger to tissue (cells) by circulated blood**
-> Hypertonic = concentrated blood --> Remove too much water
-> Hypotonic = dilute blood --> Add too much water

ISOTONIC = Achieved by controlling composition of blood (forms tissue fluid) -> Role of kidneys

Blood circulates through kidney (in excess) are removed & excreted:
-> Salts = hypertonic
-> H2O = hypotonic


Excreted to control blood to be isotonic with cells cytoplasm -> maintains functions of cell & tissue

2.68a Excretion (Roles of the kidney & liver in excretion)

Notes


"Role of kidney in process of excretion and osmoregulation"

Excretion of Urea (contains nitrogen - toxic to body and cannot be stored)
-> Original form of nitrogen (circulatory system) = amino acids
-> EXCESS amino acids MUST be removed as TOXIC
-> Removal = role of liver & kidneys


PROCESS OF EXCRETION (of Urea)
1. Blood circulates to liver ---> amino acids broken down and converted --> Urea molecule
2. Urea circulates in blood stream -> Kidneys (both) --> Kidneys filter urea from blood
3. Urea + Water = Urine ----> Bladder (therefore removed from blood circulatory system
4. Filtered blood (from kidneys) returns to circulatory system

2.67b Human Organs of Excretion

Notes


1. Lungs 
-> CO2

2. Kidneys 
-> Salts
-> Urea (Nitrogen waste from amino acids -> amino acids not stored -> amino acids excreted)
-> Excess water

3. Skin
-> Salts (Sweat)
-> Urea (very small amounts)
-> Water (Sweat)

2.67a Excretion in Plants

Notes


1. DAY Leaf absorbs Light energy by Photosynthesis (metabolic reaction):
-> CO2 + H2O ------> C6H12O6 (glucose) + O2 (gas = waste molecule = excretion)
-> O2 metabolic waste = excreted

2. NIGHT Aerobic Respiration
-> C6H12O6 (glucose) + O2 ---Enzyme reactions (glucose broken down) ---> ATP + CO2 + H20
-> CO2 = metabolic waste = excreted

Excretion = Through stomatal pores

3.34 Causes of Mutation

Notes


Mutation
Gene (ACT) ---- mutation changes base sequence ----> New allele (AAT)

Causes


1. Ionising Radiation 
   -> X-rays / gamma rays
   -> Ultraviolet: UV-B rays (sunshine) -> mutations such as skin cancer

2. Chemicals (mutagens = chemicals which cause mutations)
  -> Tars (tobacco) -> cancerous conditions

* mutagens which also cause cancer = carcinogens

3.33 Antibiotic resistance

Notes


Antibiotic resistance = increase in population of new allele

*see 3.31 evolution for details on MSSA/MRSA

MSSA --- random mutation (evolution) = MRSA---- process of natural selection ---> MRSA

As antibiotics used over time 
-> MSSA: less common

-> MRSA: more common (resists antibiotic = population expands as normal) / antibiotic no longer 'works'

3.32 Types of Mutation

Notes


Gene --- mutation ----> New Alleles

Alleles (responsible for phenotype) = harmful/beneficial/neutral

-> Beneficial = improve efficiency of enzyme

-> Harmful = production of non-functional enzyme

-> Neutral = second new allele / no effect AT PRESENT -> environmental change might render it beneficial or harmful

3.31 Evolution

Notes


"Evolution by means of natural selection."

Evolution
- change in the form of organisms (new forms of organisms)
- change in frequency of alleles

Natural selection = mechanism of evolution (Charles Darwin)

Example:

Stapholococcus aureus = infection of skin, lungs (due to wounds e.g. operations)
-> Susceptible to being killed by Methecillin (Antibiotic)

S.A. which can be killed are known as the susceptible forms of the population

-> SUSCEPTIBLE: MSSA (methecillin susceptible s.a)
-> RESISTANT: Random Mutation to S.A. allows it to break down methecillin = no longer susceptible

When both forms are treated by methecillin (MSSA, MRSA)

-> SUSCEPTIBLE: less common, decrease in population
-> RESISTANT: more common, increase in population = increase in FREQUENCY of allele for resistance

*different forms = definition of evolution -> MRSA = evolved form of MSSA due to alterations in genome

PROCESS of NATURAL SELECTION
-> Random mutation = produces MRSA form
-> Non-random selection = applying antibiotics, MRSA selected for survival/MSSA

3.30 Mutation

Notes


Mutation = Rare, random change in genetic material that can be inherited

DNA -> Base sequence (gene) -> Form of gene = Allele

1. Changes in base sequence due to certain events
2. New version might result in production of NEW PROTEIN
3. Change in Phenotype

Dominant vs. Recessive = due to mutation, which changes base sequence of gene

3.29 Species Variation

Notes


Variation = differences in phenotype of individual (possible to measure and show in graphic form)

Individual phenotype = Genotype + Modified by environment

Variation in Population = V P.genotype + V P.environment

-> Differences in Phenotypes of Species (appearance) = different genotypes + different habitats

Situations

1) Discontinuous Variation in Population/Species (GENOTYPE)

Variation in Genotype ONLY
-> Blood groups (O, A, A/B)

2) Continuous Variation in Population/Species (GENOTYPE + ENVIRONMENT)

Variation in Genotype + Environment
-> Height in humans = genes for height + diet

3) Variation in Population/Species (ENVIRONMENT)

Variation in Environment ONLY
-> Language spoken (not defined by genes at all) -> NOT INHERITABLE

3.18, 3.20, 3.21 Screen Capture

3.18c Co-dominance

3.21a Genetic Probabilities

3.21b Genetic Probabilities

3.20a Pedigree Diagrams

3.20b Pedigree Diagrams

3.19 (a) and (b) Screen Capture

3.19a

3.19b

3.18 (a) and (b) Screen Capture

3.18a

3.18b

3.2 Fertilisation

Notes


Fertilisation = "fusion of male and female gamete to produce a zygote that undergoes cell division and develops into an embryo"

1. In both Adult male & Adult female:
-> Each is in terms of a Diploid (2n) (diploid = complete set of chromosomes, 46)
-> Diploids divide in testis to produce gametes (meiosis = sperm and egg)
    -> Diploid (2n) / 2 = Haploid (n)
    -> 23 per sperm/egg

2. Fertilisation = two cells are fused together (Sperm gamete & egg gamete) to form ONE CELL

In human:
-> Haploid (n = 23) + Haploid (n = 23) => Diploid (2n = 46) =  new cell known as ZYGOTE
-> Zygote combination of male and female cells but same no. of cells as adult human

3. Mitosis = cell divides (1-2-4-8-16, etc.), 2n -- mitosis --> 2n ALL CELLS CONTAIN DIPLOID (2n = 46) NUMBER OF CHROMOSOMES
-> Embryo = large collection of diploid cells

*Note: process is true for all sexually reproducing animals, variance in no. of chromosomes

3.9b Female Reproductive System

Notes

*before pregnancy, size of uterus = approx. orange

Ovary = meiosis (production of female gametes = eggs)

Oviducts (fallopian tube) = carries eggs to uterus BUT also location of where feritlisation may occur

*Fertilisation = occurs in oviducts NOT in uterus

Uterus = centre structure, wall of uterus which is a muscle stretches during pregnancy, contracts during birth

Lining of Uterus = develops fertilised eggs --> embryo --> child, placenta implants on wall of uterus

Uterus space = where embryo develops into unborn child, stretches to accommodate growing child

Cervix = where sperm cells from the penis enter, entrance to uterus, where sperm cells make way up to oviducts AND where eggs descend down towards

Vagina = collects sperm cells at top of vagina & allows sperm to enter through the cervix

3.9a Male Reproductive System

Notes


Bladder = stores urine

Testis = carry out meiosis produces gametes (sperm cells)

Epididymus = ('coil tube' system), stores sperm cells

Vas deferens = carry sperm cells to penis during sexual stimulation (during sex tube contracts and pushes sperm to penis)

Prostate = Adds 20% - 30% of volume of semen, contains sugars, alkali (alkali nature may neutralise acidic secretions vagina)

Seminal Vesicles = Adds remaining 70% of volume of semen so sperm can travel, produces sugar based secretion, alkali

*SEMEN = sperm cells + (seminal vesicle & prostate secretions)

Urethra = Runs length of penis, common tube joining R + L testis & vas deferens, exit for urine stored in bladder

Penis = Carry sperm cells into vagina during sexual intercourse

3.12 Amniotic Fluid

Notes


Amniotic fluid: Protects developing embryo, surrounds embryo in uterus space

-> Fluid (protection of developing embryo)
     -> Cannot be compressed, 
     -> Absorbs pressure when squeezed
= Prevents damage to embryo by absorbing forces on uterus wall
= Supports foetus as it cannot support own weight during development (bones = not calcified)

e.g. Trying to kick swiftly in water, but pressure (force) of kick is absorbed, slowing leg down

3.11 Placenta

Notes


Embryo: Unborn child, encompassed by uterus (amniotic fluid filled environment), with placenta on spinal side.

Placenta (provides nutrition to embryo)


-> Grows out of embryo in form of umbilical cord

-> Cord spreads out to form placental structure

-> Placenta grows into wall of uterus (past wall lining)

-> Glucose, amino acids & fats (maternal blood stream) --- crossing at (placenta) ---> embryo's blood stream

-> Efficiency/speed of blood/nutrition transfer:
   -> Large S.A. of placenta
   -> Very thin barrier (distance between) mother and embryo

-> Urea, carbon dioxide (embryo) --- crossing at (placenta) ---> maternal blood stream

** Placenta and placental blood vessels(including p. arteries & p. veins) belong biologically to embryo NOT mother